Diet High in Antioxidants Helps Preserve Vision and Slows Down the Progression of Macular Degeneration

New study show that a diet high in antioxidants helps preserve vision and slows down the progression of macular degeneration

Antioxidants in Diets

Antioxidants found in fruit and vegetables such as carrots can help slow down sight loss in older adults, say scientists.

In a five-year study which included more than 400 people, scientists in Belfast and Waterford showed that the intake of high levels of both carotenoids – rich antioxidants found in fruit and vegetables – preserved macular pigments, slowing down the progression from early to late age-related macular degeneration (AMD).

Fresh Cut Fruit

Fresh-cut fruits is one of the fastest growing food categories in U.S. supermarkets, but what effect does processing and storage have on the nutritional value of the fruit?

Surprisingly, an international team of scientists has found that cutting and packaging fruit had almost no affect on the main antioxidants.

Their report, published in the Journal of Agricultural & Food Chemistry, shows that fresh-cut fruit retains vitamin C and other healthful antioxidants after days on the shelf.

The researchers obtained pineapples, mangoes, cantaloupes, watermelons, strawberries and kiwifruits from wholesale commercial sources in California.  The fruit was taken to a laboratory at the University of California in Davis. Half of each lot was processed as fresh-cut and half left whole.

Both lots were refrigerated under identical conditions for nine days and then tested for nutrient content. Tests showed only small losses of antioxidant compounds in the cut fruit compared to fruit left whole. Levels of some antioxidants in fresh-cut mango and watermelon actually increased due to exposure to light.

In general, researchers found that fresh-cut fruits visually spoil before any significant nutrient loss occurs.

SOURCE:  Quality Changes and Nutrient Retention in Fresh-Cut versus Whole Fruits during Storage, Gil et al, J. Agric. Food Chem., 2006, 54 (12), pp 4284–4296.

Vegetables & Nuts

University of Liverpool scientists claim that macular degeneration could be reduced by up to 20% by increasing the amount of fruit, vegetables and nuts in the diet.

Age-related macular degeneration (AMD) is a leading cause of blindness, as individuals gradually lose their central vision due to the failure of cells in the macula (the light sensitive membrane at the center of the retina).

Professor Ian Grierson, Head of Ophthalmology at the University of Liverpool, said: “Poor eating habits have a huge impact on health in general and the health of your eyes is no exception. Eye problems such as AMD, cataract and even glaucoma can all be affected by what we eat. But a relatively minor change in diet – adding a little more fruit into our meals – can make a profound difference and can keep eye diseases like AMD at bay for up to 20% longer.

“There are of course other risk factors related to AMD such as age, light exposure, smoking and being overweight. But if we can improve the kind of food that we eat, we could dramatically reduce the number of people who may suffer from eye diseases in the future.”

Grierson recommends incorporating fruits and nuts as minor additions to what we already eat, such as peaches with ham or ginger with melon.  He believes this will help slow down or even prevent the degeneration process by increasing micronutrient, vitamin and antioxidant intake in the diet.

SOURCE:  “Diet Could Reduce Onset Of Eye Disease By 20%”, University of Liverpool (2009, February 18),

New Contact Lenses Deliver Medication to the Eye

New technology may replace eye drops currently used by people suffering from glaucoma and dry-eye.

Studies have found that a majority of glaucoma patients regularly skip their eye drops, putting themselves at risk for blindness, and that even when drops are used regularly, only a small percentage of the medication tends to be absorbed into the eye.

In an article published in the July issue of Investigative Ophthalmology and Visual Science, scientists announced that they have developed a contact lens that delivers medication to the eye at a constant rate for over 4 weeks. The lenses should not affect the wearer’s vision.

The special lenses were created by dissolving a biodegradable polymer called PLGA in an organic solvent, to which medication was added. After the solvent evaporated, researchers coated the polymer film/medication mix with a hydrogel called pHEMA — the same material used to make regular contact lenses. Researchers believe they can vary the molecular weight of the polymer to change the rate of drug release as needed.

To date the researchers have only tested the diffusion properties of the lens in a lab dish, but expect to be able to test the lenses in humans within a year.

SOURCE: A Drug-Eluting Contact Lens, Ciolino, et al, Investigative Ophthalmology and Visual Science. 2009;50:3346-3352.)

Heavy Computer Use and Glaucoma

Study: Possible association between heavy computer users and glaucoma visual field abnormalities.

A 2004 cross-sectional study in 9124 Japanese workers indicated that there was a possible association between heavy computer users and glaucoma visual field abnormalities. In other words – if you use computers heavily, ie, programers, software engineers, gamers,

The study looked at typical daily computer use, as well as long-term computer use history. More than 500 participants (5.4%) had problems with their peripheral vision. Of that group, one third were found to have glaucoma … perhaps more than a third, since some workers with peripheral vision problems didn’t receive all the testing to accurately diagnose glaucoma.

Even more significant was that heavy computer users who were farsighted or nearsighted seemed to have a higher risk. Nearsightedness was found in 82% of those with glaucoma.

For more information on nutrition and vision, go to Natural Eye Care for Computer Eye Strain

Five Crucial Facts About Glaucoma

In a New York Times interview with Dr. Stuart McKinnon, associate professor of ophthalmology and neurobiology at the Duke University School of Medicine, Dr. McKinnon presented five crucial facts about glaucoma.

Irreversible damage to the optic nerve of the eye occurs long before symptoms are detected.  This means it’s vital to have regular eye exams to catch glaucoma as soon as possible to minimize vision loss.

Although increased inter-ocular pressure (IOP) is a danger sign, it doesn’t always mean you’ll develop glaucoma.  Several studies link elevated intraocular pressure with progressive vision loss, but the risk varies widely among individuals.

African-Americans have a higher risk of glaucoma.  Research has shown that African-Americans are 3 to 6 times more likely than whites to develop glaucoma, and that glaucoma appears about 10 years earlier and progresses more rapidly in blacks than whites.  Recent studies also show that Hispanics may also be at higher risk, as well as people whose immediate family members have glaucoma.  Those with increased risk of glaucoma should start eye screenings around age 40; by age 60, everyone should be screened periodically for glaucoma.

Regular monitoring is vital if you have glaucoma or early signs of it.   Glaucoma is a progressive disease, and even patients who are being treated may continue to lose vision over time unless being carefully monitored and treated.

Following treatment recommendations carefully can help spare your vision.  A wide range of glaucoma treatments are available, but these treatments (such as daily eye drops) won’t help unless actually used according to instructions.

SOURCE:  The Importance of Daily Glaucoma Treatment, New York Times, July 15, 2009, http://health.nytimes.com/ref/health/healthguide/esn-glaucoma-know.html

Mini-Strokes May Cause Vision Loss for Those with Normal Tension Glaucoma

The Hong Kong study of 286 people with normal-tension glaucoma found a high incidence of silent cerebral infarcts among those whose loss of vision progressed more rapidly. The finding is in the July issue of Ophthalmology.

A study of people who suffer the mini-strokes called silent cerebral infarcts could help explain the medical mystery of normal-tension glaucoma, Hong Kong ophthalmologists report.

The Hong Kong study of 286 people with normal-tension glaucoma found a high incidence of silent cerebral infarcts among those whose loss of vision progressed more rapidly. The finding is in the July issue of Ophthalmology.

Editor’s Note: Although the traditional approach to managing normal tension glaucoma is to lower intraocular pressure with glaucoma medications, the reason for the actual vision loss it still not known. This study may offer some insight into this vision loss.

We have long subscribed to the idea the vision loss for people with normal tension glaucoma is at least partially due to poor circulation to the optic nerve, and that taking nutrients and herbs that help strengthen circulation to the optic nerve and help fortify the optic nerve can help preserve vision.

Such nutrients include gingko biloba, taurine, vitamin B12, alpha lipoic acid, bilberry, lutein, zeaxanthin, grapeseed extract and omega-3 fatty acids.

For more related information, see Natural Eye Care for Glaucoma.

Omega-3 Fatty Acids and Macular Degeneration Prevention

Animal Testing: Fatty Acids & AMD

A diet high in omega-3 fatty acids has been found to protect against a variety of diseases including atherosclerosis and Alzheimer’s disease. Retrospective studies have suggested that diets high in fish oil or omega-3 fatty acids may also contribute to protection against age-related macular degeneration.

A group of researchers led by Dr. Chi-Chao Chan at the National Eye Institute examined the direct effect of omega-3 fatty acids on a mouse model of age-related macular degeneration. A diet with high levels of omega-3 fatty acids resulted in slower lesion progression, with improvement in some lesions. These mice had lower levels of inflammatory molecules and higher levels of anti-inflammatory molecules, which may explain this protective effect.

The researchers suggest that “a diet enriched in EPA and DHA can reduce the progression of retinal lesions in their mouse model of age-related macular degeneration” and that “the results in these mice are in line with the epidemiological studies of age-related macular degeneration risk reduction by long chain n-3 fatty acids.” The results “further provide the scientific basis for the application of omega-3 fatty acids and their biologically active derivatives in the prevention and treatment of age-related macular degeneration.”

Long Chain Fatty Acids

A study published in the Journal of Lipids Research looked into the roles played by both long chain and very long chain polyunsaturated fatty acids (LC-PUFAs and VLC-PUFAs), both of which are naturally present in the eyes.  There are not a lot of VLC-PUFAs in the eyes, and they have not received a lot of scientific attention, but this study focused on the important role they play in eye health.

Researchers concluded that a lack of either LC-PUFAs and VLC-PUFAs can lead to macular degeneration.  Source: https://www.lef.org

Fish oil is the key source of these compounds.

Good versus Bad Fats: 2 Studies

In the first study, Australian researchers evaluated data from 2,454 participants in the Blue Mountain Eye Study of men and women aged 49+. Those who consumed at least one fish serving weekly had a 31 percent lower adjusted risk of developing early AMD compared with those who consumed less.

In another study, Australian researchers of the Centre for Eye Research Australia and her associates evaluated data from 6,734 men and women aged 58 to 69 who participated in the Melbourne Collaborative Cohort Study. Dietary questionnaires completed between 1990 and 1994 were analyzed for the intake of various foods and individual fatty acids. Follow up examinations conducted between 2003 and 2006 detected 2,872 cases of early age-related macular degeneration and 88 cases of late disease.

Patients whose diets included many trans-unsaturated fats experienced a marked increase in late macular degeneration incidence, while those with amounts of trans-fats in their diets in the top 25% of all the people evaluated had  76 percent greater risk than those whose trans-fat consumption was among the lowest fourth.

Olive oil was found to provide protection against late developing AMD.  Comparing patients who included at least 100 milliliters olive oil weekly to those who consumed less than 1 milliliter per week, these “high olive oil users”  had 52 percent lower risk of late AMD.

For early developing AMD, those people who had the highest 25 percent inclusion of  omega-3 fatty acids in their diet had a 15 percent lower risk as compared with those patients who had the least consumption of omega-3 fatty acids (lowest 1/4 of consumption).

Fish as Omega-3 Source

Researches established that one serving of omega-3 fatty acid-rich fish in the diet weekly may reduce  AMD  risk  by over 50 percent.

The EUREYE study was a population-based survey of risk factors for AMD and ARM in elderly Europeans.  2,275 people aged 65+  were given eye exams and completed a questionnaire about their diet.  One aspect of the research looked at the quantity of oily fish, which is known to be high in omega-3 fatty acids. They found that 64% of the group ate less than one serving of oily fish per week; 25% of the group ate 1 serving weekly, and twice or more weekly by 12% of the survey group.

The 25% consuming oily fish at least 1 time a week were 50% less likely to develop neovascular AMD and those eating twice a week had a 58% lower risk.

Good choices for fish rich in omega-3 fatty acids are cold water fish such as salmon, herring, anchovies, mackerel and sardines.

Source: Augood, et al; Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration; American Journal of Clinical Nutrition, Vol. 88, No. 2, 398-406, August 2008.

High Omega-3 and Low Carbohydrate Diet

Researchers from Tufts University have found that a diet rich in omega-3 fatty acids and low in starchy carbohydrates can significantly reduce the risk of age-related macular degeneration (AMD).

The study, published in the journal Ophthalmology, is the first to calculate the combined effect of specific dietary nutrients and eating habits on a person’s risk for age-related macular degeneration.

During the study of 4003 participants in the ongoing Age-Related Eye Disease Study (AREDS), each dietary factor was assigned a percentile score; these scores were accumulated to find each participant’s compound score. The compound score was then evaluated for its association with the risk of AMD.

Researchers showed that vitamins C and E, zinc, lutein, zeaxanthin and the omega-3 fatty acids known as D.H.A. and E.P.A. were linked to lower risk for AMD.

The lowest risk of AMD was found in participants who regularly consumed a combination of these nutrients as part of a low-glycemic index diet.

The glycemic index (GI) is a measure of the effects of carbohydrates on blood glucose levels. Carbohydrates that break down rapidly during digestion, such as white bread and pastries, have a higher GI, as they release glucose into the bloodstream rapidly. Foods that break down more slowly, such as vegetables and proteins, have a lower GI value.

SOURCE: “Dietary Compound Score and Risk of Age-Related Macular Degeneration in the Age-Related Eye Disease Study”, Chiu, et al, Ophthalmology, Volume 116, Issue 5, Pages 939-946.

Omega-3, Nuts, Linoleic Acid and AMD

Researchers have released a new study showing that regularly including  fish, omega-3 polyunsaturated fatty acids, and nuts in one’s diet helps protect against age-related AMD.

The study, published in the Archives of Ophthalmology, assessed the relationship between dietary fatty acids and the 10-year incident of AMD.

Scientists examined 3654 elderly Australian participants at baseline and re-examined 2454 of these participants five and/or ten years later.  Participants completed a food frequency questionnaire.

The findings confirmed many previous studies on AMD.  After adjusting for age, sex, and smoking:

  • one serving of fish per week was associated with reduced risk of early AMD primarily among participants with less than the median linoleic acid consumption
  • findings were similar for consumption of long-chain omega-3 polyunsaturated fatty acids:  one to two servings of nuts per week was associated with reduced risk of early AMD
  • a positive tie between nut consumption and reduced risk of pigmentary abnormalities were seen among nonsmokers, participants with less than the median ratio of serum total to high-density lipoprotein cholesterol, and those with beta carotene intake greater than the median level.

This study provides evidence of protection against early AMD through:

  • regular consumption of fish and nuts
  • greater consumption of omega-3 polyunsaturated fatty acids
  • low intakes of foods rich in linoleic acid

SOURCE:  Dietary Fatty Acids and the 10-Year Incidence of Age-Related Macular Degeneration, The Blue Mountains Eye Study, Tan, et al, Arch Ophthalmol. 2009;127(5):656-665.

For more related research studies, click here for Natural Eye Care Related research on nutrition and macular degeneration.

Eat Fish to Fight Macular Degeneration

A new study provides further evidence that a diet high in omega-3 fatty acids may reduce the risk of age-related macular degeneration (AMD).
A NIH-funded study group led by Dr. Chi-Chao Chan at the National Eye Institute in Bethesda, Maryland, examined the effect of omega-3 fatty acids on a mouse model of AMD. Mice that were given a diet including high levels of omega-3 fatty acids showed slower retinal lesion progression, with improvement in some lesions.

Study authors suggest that the results “further provide the scientific basis for the application of omega-3 fatty acids and their biologically active derivatives in the prevention and treatment of AMD.”

Excellent sources of omega-3 fatty acids include cold water oily fish such as salmon, herring, mackerel, anchovies and sardines.

SOURCE: Tuo J, et al: A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration, Am J Pathol 2009 175: 799-807.

High Intake of Whole Grains Reduces Risk of Hypertension

A new study shows increased intake of whole grains and bran is associated with a significant reduction in the incidence of hypertension in men.

The study, published in the American Journal of Clinical Nutrition, reviewed data from the Health Professionals Follow-Up Study involving 31,684 healthy men aged 40 to 75 without known hypertension, cancer, stroke, or coronary heart disease. These participants were followed for 18 years, during which 9,227 cases of incident hypertension were recorded.

Researchers found that whole-grain intake reduced the risk of hypertension by 19%, while intake of bran reduced the risk of hypertension by 15%.

Study authors believe these findings have implications for future dietary guidelines and prevention of hypertension.

SOURCE: “Whole grains and incident hypertension in men”, Flint, et al, Am J Clin Nutr (July 1, 2009). doi:10.3945/ajcn.2009.27460

Bilberry: Macular Degeneration & Cataracts

Bilberry

European Bilberry (Vaccinium myrtillus)

Bilberry is one of the anti-oxidant rich fruits which are commonly recommended for vision conditions as well as being helpful for many other health conditions. It’s a common component in many nutritional formulations intending for vision.

There has been preliminary evidence that bilberries may help inhibit or even reverse macular disorders such as macular degeneration. Wikipedia points out that because they contain a lot of anthocyanin pigments (very dark blue) they may reduce risk for problems of the heart and cardiovascular system, eyes, and cancer.

Bilberry, a cousin to our native American blueberry or huckleberry, is, according to Wikipedia,

“… is a name given to several species of low-growing shrubs in the genus Vaccinium (family Ericaceae) that bears fruits. The species most often referred to is Vaccinium myrtillus L., otherwise known as the European blueberry. Other names are blaeberry, whortleberry, whinberry (or winberry), wimberry, myrtle blueberry, fraughan, and other names regionally.”

They don’t grow well domestically and so are harvested wild. Wikipedia points out, in fact, that it is a right, in most European countries to harvest bilberries anywhere, on anyone’s property, except in the owner’s own private garden. Public domain!

Why do bilberries help? Apparently primarily because they contain powerful anti-oxidants. More specifically, their flavonoids contain an unusually large amount of antioxidants. Flavonoids are organic compounds not directly involved in normal growth, but which assist in healthy maintenance, and whose lack causes problems.

An abstract in Advances in Gerontology, a Russian publication, discusses treatment of rats with cataracts and macular degeneration.
The abstract points out that:

“Bilberry’s flavonoids are known as potent antioxidants, scavenging free radicals and used for multiple age-related ocular disorders.”

The Russian researchers used rats with early senile cataract and macular degeneration. They were given a diet with 25% bilberry extract over a 1.5 to 3 month period (with vitamin E as a comparison). 70% of the rats given vitamin E had cataracts and macular degeneration, and those who received bilberry extract had none.

In one Italian study (I could not find the original research) 50 people with early cataract took bilberry extracts 3 times a day – the treatment stopped the progression of cataracts in 97% of the participants. Source: 100 Healing Herbs. Another study published in Alternative Medicine Review, 2001, mentions bilberry as a possible aid for cataracts.

Bilberry is a major ingredient of Dr. Grossman’s Advanced Eye & Vision Support Formula, and is been part of his recommended protocol for patients with macular degeneration and other macular conditions and cataracts.

Sources: https://en.wikipedia.org/wiki/Secondary_metabolite
https://en.wikipedia.org/wiki/Flavonoid
https://www.ncbi.nlm.nih.gov/pubmed/16075680
https://en.wikipedia.org/wiki/Bilberry
https://www.ncbi.nlm.nih.gov/pubmed/16075680
https://www.ncbi.nlm.nih.gov/pubmed/16294503
100 Healing Herbs, Castleman, Michael
https://www.ncbi.nlm.nih.gov/pubmed/11302779
https://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-bilberry.html

Macular Degeneration and Omega-3 Fatty Acids

Study found that reducing trans-fats and increasing consumption of fish, nuts, olive oil and other foods containing omega-3 fatty acids could significantly lower the risk for Macular Degeneration.

The leading cause of blindness in people over 60 is age-related macular degeneration (AMD). A recent Australian study called the Blue Mountain Eye Study examined about 2500 participants over a 5 and 10 year period.

The study found that reducing trans-fats and increasing consumption of fish, nuts, olive oil and other foods containing omega-3 fatty acids could significantly lower the risk for AMD. It may be that healthy fatty acid prevent the buildup of plaque in the arteries and reduces inflammation, blood vessel formation and oxygen-related cell damage in the retina, helping to protect the eyes.

For more information on nutrition and macular degeneration and related research studies, go to Natural Eye Care for Macular Degeneration