Nitric Oxide Shown to Lower Intraocular Pressure Naturally

Why is nitric oxide important for vision?

nitric oxide beets
Beets contain dietary nitrates. Your body converts them to nitric oxide.

Nitric oxide, one of the principal oxides of nitrogen, is produced naturally to assist with many health aspects. It contributes to vasodilation, relaxing the muscles that line your blood vessels allowing them to widen and improve circulation.  In that capacity it allows nutrients and oxygen to travel throughout the body efficiently.

As a free radical, in excess, nitric oxide (NO) contributes to inflammation, so should only be taken in recommended dosages.  In a balanced system, it is beneficial and can actually reduce inflammation. And in the case of glaucoma, it can be helpful in reducing elevated eye pressure (IOP) naturally.

Note: Nitric oxide should not be confused with nitrous oxide, a gas that dentists use to help patients relax. Continue reading “Nitric Oxide Shown to Lower Intraocular Pressure Naturally”

Basic Duo: Lutein and Zeaxanthin

Salad rich in Lutein and ZeaxanthinThese powerhouses provide a great starting point for your vision nutrition. Lutein and zeaxanthin (along with mesozeaxanthin) are carotenoids, a class of mostly yellow, orange, or red fat-soluble pigments, including carotenes, which give color to plant parts such as ripe tomatoes.

These macular pigments act as an internal pair of sunglasses to protect the retina from the damaging effects of UV radiation and blue light.  They support microcirculation in the tiny capillaries within the eye.  They protect the functions of the immune and anti-inflammation systems within the different regions of the eye. Continue reading “Basic Duo: Lutein and Zeaxanthin”

Glutathione Helpful for Covid-19

Researchers have noticed that patients with severe or fatal covid-19 are usually deficient in the amino acid and powerferful antioxidant, glutathione.

In fact, some researchers feel that glutathione deficiency may be the Trojan horse of covid-19-related death.[1. Khanfar A, Qaroot BA. (2020). Could glutathione depletion be the Trojan horse of COVID-19 mortality? Eur Rev Med Pharmacol Sci. Dec;24(23):12500-12509.]

Continue reading “Glutathione Helpful for Covid-19”

Gut Microbiota, Vision, and Mental Health

gut microbes and dietDid you know that how well your gut works is directly related to your healthy vision and your healthy brain?

Healthy gut microbiota function is linked to normal central nervous system (CNS) function. The microbiota is defined as all microorganisms in a particular location, such as the GI tract, and their respective genetic material. The microbiome is initially developed transmission through the placenta, amniotic fluid, and meconium. The human gut microbiota comprises more than 100 trillion microorganisms associated with multiple functions, from nutrient metabolism to protection against pathogens. Continue reading “Gut Microbiota, Vision, and Mental Health”

Cardiovascular Disease Linked to Eye Disease

An eye exam can reveal disease

People with cardiovascular disease may be at a higher risk of developing certain eye diseases including macular degeneration, retinopathy, retinal bleeding, a retinal vein occlusion, and blurred vision.

Why is heart disease linked to eye disease?

Good vision requires, among other factors, adequate blood circulation, and normal blood pressure. The eyes have a network of tiny blood vessels, each no wider than a strand of hair, which supply blood to the retina, the light-sensitive tissue at the back of the eyeball. Continue reading “Cardiovascular Disease Linked to Eye Disease”

Natural Eye Care Michael Edson’s Alzheimer’s Article in the Townsend Letter

The latest Townsend Letter features co-owner of naturaleyecare.com Michael Edson, L.Ac., MS  and his article, Underlying Causes and Natural Treatments for Alzheimer’s and Dementia.

The publisher’s discussion of Michael’s article also mentions that studies report that the Tdap (Tetanus, diphtheria, and pertussis) vaccination reduces the risk of dementia by 42% with similar results for flu and pneumonia vaccines.  Both results may be due to reduced overall inflammation in the body.

Top Nutrients for the Brain

Top nutrients for the brain include: ashwagandha, CoQ10, curcumin, DHA, ginseng, gingko biloba, glutathione, lutein, resveratrol, taurine, and vitamins B2, B6, B9, B12, and D3. Interestingly, most of the essential nutrients that support healthy retina, optic nerve and overall eye health are needed in the brain as well and are allowed to pass through the blood-brain barrier.

Continue reading “Natural Eye Care Michael Edson’s Alzheimer’s Article in the Townsend Letter”

Glaucoma, IOP, and Herbal Extracts

 glaucoma aging seniors.The most common form of glaucoma is “open-angle” glaucoma, where the eye pressure or IOP remains higher than normal (typically 8-20 mm Hg). Eye doctors also look at changes in peripheral field typically measured with a visual fields test and any changes in the optic nerve such as optic nerve thinning or increased cupping. Ocular hypertension is diagnosed when IOP is higher than normal but there as no signs of glaucoma. In addition glaucoma can occur without high IOP, “normal or low tension glaucoma.”

The most common treatment for lowering eye pressure is the use of prescription eyedrops which either reduce the amount of aqueous fluid produced or increase the drainage. Often these eyedrops are effective in lowering eye pressure but do have unpleasant side effects for some people.

In some cases, medication can be avoided completely with natural approaches though it is essential that the patient get checked on a regular basis to make sure that the IOP is at recommended levels, and work closely with the eye doctor. Continue reading “Glaucoma, IOP, and Herbal Extracts”

Mesozeaxanthin: Star of Macular Carotenoids

carotenoid supplements and foodsMesozeaxanthin, less well-known than lutein and zeaxanthin, is the most powerful antioxidant of the threesome, but the combined trio presents the most potent protection for the eye than any of the three carotenoids alone.[1. Li B, Ahmed F, Bernstein PS. (2010-12-01). Studies on the singlet oxygen scavenging mechanism of human macular pigment. Arc Biochem Biophys. 504(1):56–60.]  Out of all of the roughly 7000 carotenoids known in nature, it is these three that are found in great concentrations in the macula, the key part of the retina, responsible for central vision. Continue reading “Mesozeaxanthin: Star of Macular Carotenoids”

Melatonin: More than a Sleep Aid

What is Melatonin?

melatonin and sleepingMelatonin is a hormone primarily released by the pineal gland at night, and has long been associated with control of the sleep–wake cycle. It is typically taken at night before bedtime as a supplement. In addition to melatonin’s application as a sleep aid, this supplement can also be used for lowering eye pressure — such as in cases of open angle glaucoma or glaucoma suspects.  Research shows melatonin may also protect the eye’s macula by supporting the functioning of the mitochondria, the tiny “batteries” in each cell. Alzheimer’s disease appears to be linked to poor quality sleep and melatonin production; therefore, melatonin may prove to be a useful supplement and research is underway. Keep reading for details plus information about supplements available on this website.

What Can Melatonin Help?

Insomnia

Melatonin is best known for helping us get to sleep. It is secreted by the pineal gland, acting as the body’s biochemical signal of biological darkness. In other words, our bodies biochemistry signals that you are ready for sleep. Blue light suppresses production of melatonin [1. Gooley JJ, Chamberlain K, Smith KA, Khalsa SB, Rajaratnam SM, et al. (2011). Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans. J Clin Endocrinol Metab. Mar;96(3):E463-72.] to a surprisingly profound degree.[2. Vartanian GV, Li BY, Chervenak AP, Walch OJ, Pack W, et al. (2015). Melatonin Suppression by Light in Humans Is More Sensitive Than Previously Reported. J Biol Rhythms. Aug;30(4):351-4.]

If you are exposed to blue light right before bedtime (e.g. checking your email one more time), it throws off the internal rhythm that allows you to get adequate sleep. Nearly 75% of children now use some sort of electronic device in their bedroom. The use of these devices markedly impacts sleep quality, which in turn, contributes to social adjustment problems, behavioral problems in school and at home, and surprisingly, weight gain.

Similarly, it has been found that sleeping in a room that is not dark, also disrupts sleep, or makes it less effective in reducing fatigue and alleviating the accumulated stress of the day. Most studies found that exposure to light in the room, during sleep, reduces melatonin production by 50%.

While most research on the effects of smartphones on sleep and circadian rhythms have involved children and teens, adults are also adversely impacted. One Flemish study included more than 800 adults, 50% of whom owned smartphones, and 60% of whom used their smartphone during the night. Nighttime phone use and texting at night markedly increased how long it took to fall asleep and markedly decreased the quality, duration, and efficiency of sleep. In younger adults, nighttime electronic-device use was tied to more fatigue and later rising time. In older adults, it was associated with shorter sleep duration and earlier rise time.[3. Exelmans L, Van den Bulck J. (2016). Bedtime mobile phone use and sleep in adults. Soc Sci Med. Jan;148:93-101.]

Recommended dosage is 1mg–3mg before bedtime.

Supports the Immune System

Melatonin plays a dual role in supporting the immune system, at least partially because it helps promote glutathione levels in the body, an essential master antioxidant.  It communicates with the immune system and influences white blood cells to fight infections and inflammation. Lowered levels of the super antioxidant glutathione[4. Glutathione is actually the antioxidant found in greatest quantity in the brain and found to be deficient in the brains of Alzheimer’s and Parkinson’s patients.] are present in “clinical conditions like autoimmune disorders, neurological disorders, diabetes, and microbial infections”[5. NaveenKumar SK, Hemshekhar M, Jagadish S, Manikanta K, Vishalakshi GJ, et al. (2020). Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system. J Pineal Res. Oct;69(3):e12676.] which are characterized by white blood cells. In other words, melatonin protects white blood cells from free radicals by supporting normal glutathione levels.

Lowers Eye Pressure

Intraocular pressure (IOP) is usually lowest at night, which is also when natural levels of melatonin are near their high in the circadian cycle. IOP is highest in the morning when melatonin is low. There seems to be a correlation between IOP and melatonin; supplementing with melatonin may lower IOP. [6. Samples, J.R., Krause, G., Lewy, A.J. (1988). Effect of melatonin on intraocular pressure. Curr Eye Res. Jul;7(7):649-53.] [7. Alkozi HA, Navarro G, Franco R, Pintor J. (2020). Melatonin and the control of intraocular pressure. Prog Rentin Eye Res. Mar;75:100798.]

Protects the Macula

Melatonin also protects the macula, the center part of the retina which is responsible for your central vision needed for close-up work such as reading. Age-related macular degeneration (AMD) is the loss of central vision and is caused by deterioration of the macula. A combination of melatonin (3mg), zinc (8.7mg), and selenium (50 mcg), taken before bedtime, helps stabilize AMD with some remarkable improvement in the fundus of the eye after taking the combination for 6 months. [8. Stefanova NA, ZHdankina AA, Fursova AZ, Kolosova NG. (2013). Potential of melatonin for prevention of age-related macular degeneration: experimental study (in Russian). Adv Gerontol. 2013;26(1):122-9.] [9. Yi C, Pan X, Yan H, Guo M, Pierpaoli W. (2005). Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci. Dec;1057:384-92.]

Supports Mitochondrial Functioning

A 2020 review proposed that melatonin protects the macula by supporting mitochondrial function. Mitochondria are the “energy-producers” of cells, and are essential for cellular health. As we age DNA repair functions, antioxidant activity, and lack of mitochondrial renewal lead to significant increase in free radicals. These changes cause inflammation and premature cell death in the retinal pigmented cells that protect the retina and macula.[10. Mehrzadi S, Kemati K, Reiter RJ, Hosseinzadeh A. (2020). Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment. Expert Opin Ther Targets. Apr;24(4):359-378.]

Helps Night Vision

Photosensitive retinal ganglion cells (melanopsin-expressing retinal ganglion cells “mRGC”) release melanopsin which affects pupil dilation and adaption and suppresses melatonin[10. Bonmati-Carrion MA, Arguelles-Prieto R, Martinez-Madrid MJ, Reiter R, Hardeland R, et al. (2014). Protecting the melatonin rhythm through circadian healthy light exposure. In J Mol Sci. Dec 17;15(12):23448-500.] between dark and bright light (such as recovery after glare of an oncoming car headlights).

Melanopsin’s presence in retinal nerve cells is linked to reduced levels of melatonin and the relationship may be involved in poor night vision. At night, melatonin is secreted by rod and cone photoreceptors, functioning as a dark adaptive signal and it, in turn, modulates these photoreceptors.[11. Pack, W., Hill, D.D., Wong, K.Y., (2015). Melatonin modulates M4-type ganglion-cell photoreceptors. Neuroscience, Sep 10;303:178-88.]

Aids Alzheimer’s Disease Issues

Melatonin may be a useful agent in preventing and treating Alzheimer’s disease (AD).  Classic markers of AD include the build-up of beta amyloid plaque, as well as excessive tau protein resulting in neurofibrillary fiber build-up.[12. This is discussed in detail, along with other underlying factors and causes including natural treatment strategies, in my book Natural Brain Support: Your Guide to Preventing and Treating Alzheimer’s, Dementia and Other Related Diseases Naturally.]

The production of melatonin runs parallel to AD progression. Quality of sleep is dependent upon melatonin, and it appears to be a safe and effective treatment for AD patients with sleep dysfunction.[13. Wang YY, Zheng W, Ng CH, Ungvari GS, Wei W, et al. (2017). Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer’s disease. Int J Geriatr Psychiatry. Jan;32(1):50-57.] Melatonin stimulates non amyloidogenic processing and inhibits beta amyloid precursor protein processing which culminates in amyloid aggregates – a neuroprotective function in AD pathology.[14. Shukla M, Govitrapong P, Boontem P, Reiter RJ, Satayavivad J. (2017). Mechanisms of Melatonin in Alleviating Alzheimer’s Disease. Curr Neuropharmacol. 2017;15(7):1010-1031.] It decreases AD-like tau hyperphosphorylation, protects the cholinergic system and is anti-inflammatory. It may be a useful agent in preventing and treating AD.[15. Lin L, Huang QX, Yang SS, Chu J, Wang JZ, et al. (2013). Melatonin in Alzheimer’s disease. Int J Mol Sci. Jul 12;14(7):14575-93.] Weak melatonin signaling (melatonin receptor type 1A gene) appears to contribute to the cascade of AD pathology.[16. Sulkaya S, Muggalla P, Sulkava R, Ollila HM, Peuralinna T, et al. (2018). Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age. Sleep. Jul;41(7):zsy103.]

Recommended Products

NEWDr. Grossman’s REM Sleep Support (sublingual) Formula – great sublingual night-time formula with melatonin, and a range of other nutrients to promote a good night’s sleep.

ACG Glutathione EXTRA STRENGTH Spray 2oz. – 6-12 sprays by mouth 2 times per day.

Melatonin (50) MZS 60 x 3mg Tabs, Dr. Pierpaoli –  50 3mg tabs with zinc and selenium

Glutathione is a Super-Antioxidant

glutathione spray supplementGlutathione is rather amazing – low levels are biomarkers for various conditions and it is a “super antioxidant.”

Low levels of glutathione are linked to cataracts, macular degeneration, glaucoma, and brain neurodegenerative problems. The amount of glutathione in blood plasma is considered an overall indicator of the body’s antioxidant defense system.

Glutathione (GSH) is a super free radical fighter with the capacity to neutralize the full spectrum of free radicals. Normal metabolic activity creates free radicals, they can be destructive. They are missing an electron in their outer orbit and therefore try to steal one from a nearby healthy cell, rendering that cell dysfunctional. Continue reading “Glutathione is a Super-Antioxidant”